1303607-59-1
英文名称
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-
CAS
1303607-59-1
分子式
C28H32Cl2FN3O3
分子量
548.48
MOL 文件
1303607-59-1.mol
结构式
基本信息
英文别名
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-
应用领域
用途一
MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.