130-01-8
基本信息
千里光宁碱
千里光寧鹼
千里光碱/ 千里光宁
Aureine
SENECIONIN
Sencionine
SENECIONINE
Senecionine/Aureine
16-dione,12-hydroxy-senecionan-1
12-Hydroxysenecionan-11,16-dione
Senecionan-11,16-dione, 12-hydroxy-
(15cis)-12-Hydroxysenecionan-11,16-dione
物理化学性质
| 外观性状 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于菊三七，千里光Senecio scandens Buch.-Ham. ex D. Don，欧洲千里光 Senecio vulgaris L.全草 菊叶千里光 S.chrysanthemoides DC.根 牙克贝千里光 S.jacobaea L.。 |
| 熔点 | 236 °C(lit.) |
| 比旋光度 | D25 -55.1° (c = 0.034 in chloroform) |
| 沸点 | 472.03°C (rough estimate) |
| 密度 | 1.266 g/cm3 |
| 折射率 | 1.5100 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| 酸度系数(pKa) | 12.81±0.40(Predicted) |
| 形态 | neat |
| 颜色 | White to off-white |
| 旋光性 (optical activity) | [α]25/D 55.1°, c = 0.034% in chloroform |
| BRN | 8162955 |
| InChIKey | HKODIGSRFALUTA-JTLQZVBZSA-N |
| LogP | 0.880 (est) |
| EPA化学物质信息 | Senecionine (130-01-8) |
安全数据
| 危险性符号(GHS) |  GHS06 |
| 警示词 | 危险 |
| 危险性描述 | H300+H310+H330 |
| 防范说明 | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| 危险品标志 | T |
| 危险类别码 | 25 |
| 安全说明 | 45 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | VT5710000 |
| F | 10-23 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 毒害物质数据 | 130-01-8(Hazardous Substances Data) |
| 毒性 | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) |
千里光宁价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 1mg | 525元 |
| 2024/11/08 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 5mg | 1295元 |
| 2024/11/08 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 10mg | 2100元 |
常见问题列表
Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.