1256493-34-1
基本信息
DYNGO?4A,新型的动力抑制剂
HYDROXY DYNASORE游离
3-羟基-N′-((2,4,5-三羟基苯基)亚甲基)-2-萘酰肼
Dyng
Dyngo-49
Dyngo-4a
Hydroxy-Dynasore
3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide
物理化学性质
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>10mg/mL |
| 酸度系数(pKa) | 8.28±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深黄色 |
安全数据
| 危险性符号(GHS) |    GHS07,GHS08,GHS09 |
| 警示词 | 危险 |
| 危险性描述 | H302-H361-H372-H410 |
| 防范说明 | P201-P264-P280-P301+P330+P331-P312 |
| 危险品标志 | N |
| 危险类别码 | 50 |
| 安全说明 | 61 |
| WGK Germany | 3 |
DYNGO-4A价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-13863 | DYNGO-4A Hydroxy-Dynasore | 1256493-34-1 | 10mM * 1mLin DMSO | 640元 |
| 2024/04/30 | HY-13863 | DYNGO-4A Hydroxy-Dynasore | 1256493-34-1 | 10mg | 950元 |
| 2024/04/30 | HY-13863 | DYNGO-4A Hydroxy-Dynasore | 1256493-34-1 | 50mg | 2850元 |
常见问题列表
Dynamin is a large GTPase enzyme that severs membrane‐bound clathrin‐coated vesicles. Endocytosis internalizes portions of cells’ plasma membrane along with extracellular material, is fundamentally important in cell physiology. Hydroxy Dynasore inhibits Dynamin I (Dyn I) activity with IC 50 values of 2.7 μM and 0.38 μM with or without 0.06% Tween‐80 in the GTPase assay. Hydroxy Dynasore shows an IC 50 of 5.7 μM in clathrin‐mediated endocytosis (CME) assay for inhibition of Tfn‐A594 uptake in U2OS cells. Hydroxy Dynasore shows IC 50 values of 0.38 μM and 1.1 μM in absence of Tween-80, and exhibits IC 50 values of 4.9 μM and 30.0 μM in presence of Tween-80, respectively. Hydroxy Dynasore is 2.1‐fold selective for DynI versus DynII from Sf21 cells] and DynII (recombinant protein from Sf21 cells) in this GTPase assay. Hydroxy Dynasore prevents the uptake of BoNT/A-Hc in cultured hippocampal neurons and in motor nerve terminals. Hydroxy Dynasore (1-100μM; 20 min prior to the addition of Alexa Fluor 488-BoNT/A-Hc) results in depolarization of Hippocampal neurons, it dose-dependently inhibits internalization of Alexa Fluor 488-BoNT/A-Hc with an IC 50 of 16.0 ± 1.2 μM.
Hydroxy Dynasore (intraperitoneal injection; 30 mg/kg; 1.5-2 h before BoNT/A injection) provides protection again BoNT/A-induced paralysis in the phrenic nerve-hemidiaphragm twitch model in CD-1 mice.
| Animal Model: | CD-1 mice. |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection; 1.5–2 h before BoNT/A injection |
| Result: | Protected BoNT/A-induced paralysis in vivo. |