1240494-13-6
中文名称
VZRIHFZJVIOJBE-UHFFFAOYSA-N
英文名称
VZRIHFZJVIOJBE-UHFFFAOYSA-N
CAS
1240494-13-6
分子式
C19H16BFN2O3S
分子量
382.22
MOL 文件
1240494-13-6.mol
结构式
物理化学性质
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 8.45±0.53(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
应用领域
用途一
SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs but had no effect on the Ca(2+) flux induced by C5a, fMLF, or PAF. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism.