112924-45-5
中文名称
1,1-二甲基庚基-11-羟基四氢大麻酚
英文名称
1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
CAS
112924-45-5
分子式
C25H38O3
分子量
386.57
MOL 文件
112924-45-5.mol
更新日期
2023/02/22 11:54:00
结构式
基本信息
中文别名
地塞米诺
1,1-二甲基庚基-11-羟基四氢大麻酚
1,1-二甲基庚基-11-羟基四氢大麻酚
英文别名
Dexanabinol
1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
(6aS,10aS)-3-(1,1-dimethylheptyl)-6,6-dimethyl-9-methylol-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
(6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
(6aS)-6aα,7,10,10aβ-Tetrahydro-6,6-dimethyl-1-hydroxy-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol
(6AR,10AR)-3(1,1-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
[6aS,(+)]-6a,7,10,10aβ-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol
(6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
(6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,77,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
(6AR,10AR)-3-(1,1'-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
(6aS,10aS)-3-(1,1-dimethylheptyl)-6,6-dimethyl-9-methylol-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
(6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
(6aS)-6aα,7,10,10aβ-Tetrahydro-6,6-dimethyl-1-hydroxy-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol
(6AR,10AR)-3(1,1-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
[6aS,(+)]-6a,7,10,10aβ-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol
(6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
(6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,77,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
(6AR,10AR)-3-(1,1'-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
物理化学性质
| 熔点 | 141-142° |
| 比旋光度 | D +227° (CHCl3) |
| 沸点 | 470.1±45.0 °C(Predicted) |
| 密度 | 1.030±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMSO: soluble |
| 酸度系数(pKa) | 9.72±0.60(Predicted) |
| 形态 | solid |
安全数据
1,1-二甲基庚基-11-羟基四氢大麻酚价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/01/06 | HY-106387 | 1,1-二甲基庚基-11-羟基四氢大麻酚 Dexanabinol | 112924-45-5 | 1mg | 1500元 |
常见问题列表
生物活性
Dexanabinol (HU-211) 是一种人工合成的大麻素衍生物，缺乏大麻素效应。Dexanabinol 不仅表现出大脑中的抗氧化和神经保护作用，还具有抑制 NF-κB 和降低细胞因子如 TNFα 和白细胞介素-6 (IL-6)的抗炎活性，可以保证 BBB 的完整性，减少细胞凋亡和死亡。Dexanabinol 广泛用于头部损伤或中风研究，并且已被证明在动物和人类中是安全的。
靶点
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NF-κB
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TNFα
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IL-6
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