108351-90-2
中文名称
PD 118440
英文名称
PD 118440
CAS
108351-90-2
分子式
C11H17N3S
分子量
223.34
MOL 文件
108351-90-2.mol
结构式
物理化学性质
| 熔点 | 121-123 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
| 沸点 | 384.4±30.0 °C(Predicted) |
| 密度 | 1.162±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 8.00±0.40(Predicted) |
应用领域
用途一
PD 118440 is a Dopamine antagonist. It has been identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests that include [3H]-haloperidol and [3H]-N-propylnorapomorphine binding, inhibition of striatal DA synthesis, inhibition of DA neuronal firing, inhibition of spontaneous locomotor activity, and reversal of reserpine-induced depression in rats.
常见问题列表
概述
PD 118440 是一种具有口服活性的多巴胺 (DA) 激动剂。PD 118440 具有明显的中枢神经系统作用，包括抑制纹状体 DA 合成，抑制 DA 神经元放电，并逆转 Reserpine (HY-N0480) 诱导的大鼠抑郁。