102676-31-3
基本信息
D02451
Fadrazole
CGS-16949A
Fadrozole HCl
FADROZOLE HYDROCHLORIDE
Fadrozole hydrochloride (usan)
FADROZOLE (HYDROCHLORIDE)
CGS 16949A
4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920)
+-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride
物理化学性质
熔点 | 231-233℃ |
储存条件 | room temp |
溶解度 | 二甲基亚砜:>20mg/mL |
形态 | 粉末 |
颜色 | 淡米色至淡黄色 |
稳定性 | 吸湿性 |
安全数据
危险性符号(GHS) | GHS06,GHS08 |
警示词 | 危险 |
危险性描述 | H301-H361 |
防范说明 | P202-P264-P270-P280-P301+P310-P405 |
危险品标志 | Xn |
危险类别码 | 63-22 |
安全说明 | 36/37 |
危险品运输编号 | UN 2811 6.1 / PGIII |
WGK Germany | 2 |
RTECS号 | DI4952500 |
盐酸法倔唑价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/11/08 | HY-14247 | 盐酸法倔唑 Fadrozole hydrochloride | 102676-31-3 | 5mg | 660元 |
2024/11/08 | HY-14247 | 盐酸法倔唑 Fadrozole hydrochloride | 102676-31-3 | 10mM * 1mLin DMSO | 726元 |
2024/11/08 | HY-14247 | 盐酸法倔唑 Fadrozole hydrochloride | 102676-31-3 | 10mg | 880元 |
常见问题列表
IC50: 6.4 nM (aromatase)
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC 50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.
Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.