ChemicalBook CAS DataBase List 99141-91-0

99141-91-0

Name	L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)
CAS	99141-91-0
Molecular Formula	C11H20N2O4
Molecular Weight	244.29
MOL File	99141-91-0.mol

Chemical Properties

Melting point	105 °C
Boiling point	442.1±25.0 °C(Predicted)
density	1.078±0.06 g/cm3(Predicted)
storage temp.	-10 to -25°C
solubility	Soluble to 100 mM in ethanol and to 100 mM in DMSO
form	Oil
pka	13.30±0.46(Predicted)
color	White to off-white

Hazard Information

Uses

ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD)[1].

Biological Activity

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.

in vivo

ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time^[1].
Intragastric administration of ZZL-7 (10, 20, and 40 mg/kg; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment^[1].
ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment^[1].

Animal Model:	SERT-Cre mice^[1]
Dosage:	10 mg/kg
Administration:	i.p.; once
Result:	Significantly increased firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice.

storage

Store at -20°C

References

[1] Nan Sun, et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science. 2022 Oct 28;378(6618):390-398. DOI:10.1126/science.abo3566

Spectrum Detail

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