97589-07-6

Lipoxin B₄ (LXB₄) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB₄ . LXB₄ is a positional isomer of LXA₄ produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB₄ inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B₄ (LTB₄; ) and inhibits LTB₄-induced adhesion of PMNs with an IC₅₀ value of 0.3 nM.

Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.

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[1] Serhan, et al. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. USA 81(17), 5335-5339 (1984).