Uses
(R)-IBR2 is the isomer of IBR2 (HY-103710). IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1].
Biological Activity
IBR2 is a cell penetrantpotent and specific RAD51 inhibitor th at inhibits RAD51-mediated DNA double-strand break repair and enhances cytotoxicity of multiple anticancer agents with disparate biochemical targets including the Bcr-Abl inhibitor imatinib and multiple kinase inhibitor regorafenib. IBR2 disrupts RAD51 multimerizationaccelerates proteasome-mediated RAD51 protein degradationreduces ionizing radiation-induced RAD51 foci formationinhibits cancer cell growth and induces apoptosis.
