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Amino-PEG4-azide is a very popular bifunctional crosslinker. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

O-(2-AMinoethyl)-O'-(2-azidoethyl)triethylene Glycol is a heterobifunctional polyethyleneglycol (PEG) derivative; a useful reagent used in the construction of intramolecular linkers.