ChemicalBook CAS DataBase List 95153-31-4

95153-31-4

Name	Perindoprilat
CAS	95153-31-4
Molecular Formula	C17H28N2O5
MDL Number	MFCD00865777
Molecular Weight	340.41
MOL File	95153-31-4.mol

Synonyms

S-9780 Diacid form PERINDOPRILAT Perindoprilat ,95% PERINDOPRILAT HYDRATE Perindopril Impurity 5 Perindopril EP IMpurity B Perindopril Related CoMpound B Perindopril EP IMpurity-B(USP RC B) Perindopril impurity Ⅲ(Perindoprilat) Perindoprilat (Mixture of Diastereomers) (2s-(1(r*(r*)),2-alpha,3a-beta,7a-beta))-) 1h-indole-2-carboxylicacid,octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl (2S,3AS,7aS)-1-((S)-2-(((S)-1-carboxybutyl)amino)propanoyl)octahydro-1H-indole-2-carboxylic ac (2S,3aS,7aS)-1-[(S)-2-[[(S)-1-Carboxybutyl]amino]-1-oxopropyl]hexahydroindoline-2-carboxylic acid (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]aMino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid 1H-Indole-2-carboxylicacid, 1-[(2S)-2-[[(1S)-1-carboxybutyl]aMino]-1-oxopropyl]octahydro-,(2S,3aS,7aS)- [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)aMino]-1- oxopropyl]octahydro-1H-indole-2-carboxylic Acid (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid Perindopril Related Compound B (10 mg) ((2S,3aS,7aS)-1-{(S)-2-[(S)-1-carboxybutylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid)

Chemical Properties

Appearance	White to Off-White Solid
Melting point	153-155°C
Boiling point	568.1±45.0 °C(Predicted)
density	1.222±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.27±0.20(Predicted)
color	White to Pale Beige
Stability:	Hygroscopic
CAS DataBase Reference	95153-31-4

Safety Data

HS Code

2933999552

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White to Off-White Solid

Uses

An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical]

Definition

ChEBI:Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an organic heterobicyclic compound, a dipeptide, a dicarboxylic acid and a L-alanine derivative.

in vivo

Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells^[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction^[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction^[4].

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05).

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction.

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.

storage

Store at -20°C

Spectrum Detail

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