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Prostaglandin F_2α (PGF_2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 16-phenoxy PGF_2α is a metabolically stable analog of PGF_2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF_2α. Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable PGF2α analogue containing a acetamide structure[1].

[1] Balapure AK, et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81. DOI:10.1016/0006-2952(89)90478-4