95088-49-6

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

[1] Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6. DOI:10.1073/pnas.96.1.91
[2] Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound?targeted microbubble destruction?mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572. DOI:10.3892/mmr.2017.6661