ChemicalBook CAS DataBase List 94948-59-1

94948-59-1

Name	HUMAN TNF-ALPHA
CAS	94948-59-1
Molecular Formula	NULL
MDL Number	MFCD00148692

Chemical Properties

storage temp.	-20°C
form	powder
color	colorless

Safety Data

WGK Germany	3
RTECS	MT6435000

Hazard Information

Description

Tasonermin was launched in Germany for the treatment of soft tissue sarcoma of the limbs. Recent literature is scarce for this compound. It is the first tumor necrosis factor (TNF) launched for cancer treatment to date and works through destruction of tumor blood vessels. This recombinant protein is expressed in E. coil and purified. Tasonermin is too toxic for systemic use and consequently is being used in isolated limb perfusion (ILP) for sarcoma and malignant melanoma. The product has shown notable efficacy when used in combination with melphalan to prevent amputation. In four European clinical trials involving 260 patients destined for amputation or mutilating surgery, Beromun enabled durable limb salvage in 80% of the patients. Due to the complexity of ILP, the application of tasonermin is restricted to clinical centers with sufficient experience and facilities including radionucleide-based continuous monitoring of leakage from the isolated circuit during ILP and postoperative intensive care surveillance.

Originator

Genentech (US)

Uses

TNF-α include stimulating growth of human fibroblasts and other cell lines activating polymorphonuclear neutrophils and osteoclasts and inducing interleukin-1, prostaglandin E2, and collagenase production.

Uses

Tumor Necrosis Factor-a human has been used:

as a permeability inducing agent for endothelial cell monolayer permeability assay
as a reactive oxygen species inducer in primary rat cardiac microvascular endothelial cells (RCMVECs)
in the activation of nuclear factor kappa B (NF-κB) in human embryonic kidney cells (HEK293), neuroblastoma SH-SY5Y cells and HeLa cells
in the stimulation of the human keratinocyte cell line(HaCaT) and human coronary artery endothelial cells (HCAECs)

Brand name

Beromun

General Description

The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily. TNF-α has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue.

Biochem/physiol Actions

Tumor Necrosis Factor-α (TNF-α) is a potent pro-inflammatory cytokine that plays a role in the rheumatoid arthritis pathology, psoriatic arthritis (PsA) and psoriasis. It stimulates interleukins IL-1 and IL-6. Polymorphism in the TNF-α gene is associated with destructive arthropathy in PsA. The post-translational modifications in TNF-a is crucial for its functionality.

Supplier

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky (shanghai) International Co.,Ltd

Telephone021-50135380

Websitehttp://www.shchemsky.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Beijing OKA biological technology co., LTD

Telephone010-010-010-62971590 18548936886

Websitehttp://www.bjoka-vip.com/

Absin Bioscience Inc.

Telephone021-38015121 15000105423

Websitehttps://www.absin.cn/

TCI (Shanghai) Chemical Trading Co., Ltd.

Telephone021-021-61109150

Websitehttps://www.tcisct.com

Shanghai Universal Biotech Co.,Ltd

Telephone 13774214275

Websitehttps://www.univ-bio.com/

amyjetsci

Telephone027-59626688 18771149750

Websitehttps://www.amyjet.com/

JiangSu Star Science Co.,Ltd

Telephone400-400-605-7200-7200 15335295587

Websitehttps://www.b2star.com/

Shanghai Huzhen Industrial Co., LTD

Telephone021-60345367 13916550749

Websitehttps://www.shuzbio.com/

Shanghai Yingxin laboratory equipment Co., Ltd

Telephone021-021-59178156 15300768757

Websitehttp://www.yingxinbio.com/

Shanghai Guchen Biotechnology Co., LTD

Telephone021-34675735 19147740836

Websitehttp://www.shgcsw-edu.com

https://hanhongsci.com/

Telephone021-54306202 18917919676

Websitehttps://www.hanhongsci.com/

1of3

Related Products

Send Inquriy