949004-12-0

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ⁷-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC₅₀ value of 23 nM. At 50 nM, (25S)-Δ⁷-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.

ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group).

+4°C