ChemicalBook CAS DataBase List 945212-59-9

945212-59-9

Name	MaciMorelin Acetate
CAS	945212-59-9
Molecular Formula	C28H34N6O5
MDL Number	MFCD28502054
Molecular Weight	534.607
MOL File	945212-59-9.mol

Chemical Properties

storage temp.	-10 to -25°C
solubility	DMSO: 2mg/mL, clear
form	Solid
color	White to off-white
InChIKey	UJVDJAPJQWZRFR-DHIUTWEWSA-N
SMILES	[nH]1c2c(c(c1)C[C@@H](NC(=O)[C@H](NC(=O)C(N)(C)C)Cc3c4c([nH]c3)cccc4)NC=O)cccc2

Safety Data

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

Biological Activity

Macimorelin (AEZS-130; ARD-07; EP1572; UMV1843; Aib-DTrp-DgTrp-CHO) is an orally active peptido-mimetic growth hormone (GH) secretagogue (GHS) th at targets human and animal GHS-receptor (IC50 in nM = 10.2/ghrelin12.3/hexaghrelin15.6/macimorelin against ghrelin binding to human GHS-R) with potent and selective GH-releasing activity in vivo (GH level = 158.8 μg/L 15 min post 300 μg/kg s.c. in neonatal rats; 11.3 μg/L without treatment).

in vivo

Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) acetate decreased the number and duration of seizures in IHKA mouse model^[2].

Animal Model:	Intrahippocampal kainic acid (IHKA) mouse model^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), twice daily for 2 weeks.
Result:	Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.

References

[1] Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103(8):3083-3093. DOI:10.1210/jc.2018-00665
[2] An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28(9):3100-3112. DOI:10.1111/ene.14992
[3] Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34:

Supplier

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070 13770331960

Websitehttp://www.echemlin.cn

Shanghai Send Pharmaceutical Technology Co., Ltd.

Telephone021-58088081 18317173152

Websitehttp://www.shsendpharma.com

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Hangzhou Peptidego Biotech Co.,Ltd.

Telephone0571-87213919 15967184799

Websitehttp://peptidego.com

Yichang Chanod Biomedical Technology Co,LTD

Telephone0717-6855399 15377615856

Websitehttp://www.sndswyy.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Telephone0571-87213919 17306812703

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1355681/0_EN.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Nanjing Xinmeihe Pharmaceutical Co., Ltd.

Telephone025-57672321 13739186949

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30484/0_EN.htm

Shaanxi Didu Pharmaceutical Co., Ltd.

Telephone029-81124775 17791530730

Website

Hydebio Labs Co.,Limited

Telephone+86-18100690299 +86-18100690299

Websitewww.hydebiolabs.com

Chongqing jooe co., ltd

Telephone +86-15223382610

Websitehttps://www.jooe.com/

1of3

Related Products

Send Inquriy