Hazard Information
Description
Cagrilintide is an amylin-analog, now being developed in combination with the GLP-1 agonist semaglutide to achieve sustained weight loss in persons with overweight and obesity. This drug is an investigational therapy that reduced body weight in a phase 2 trial when administered as monotherapy in participants without diabetes and with a BMI of at least 30 kg/m2 or at least 27 kg/m2 with hypertension or dyslipidaemia[1-2].
Mechanism of action
Cagrilintide, a non-selective agonist, is designed for weekly subcutaneous injection at low pH. It is based on the h-amylin backbone, drawing inspiration from calcitonin, and exhibits a prolonged action profile, likely attributed to reversible albumin binding similar to semaglutide. This amylin analog is currently under development in combination with the GLP-1 agonist semaglutide to achieve sustained weight loss in individuals with overweight and obesity. Amylin, co-secreted with insulin from pancreatic beta cells, exerts its satiating effect through both the homoeostatic and hedonic brain regions. On the other hand, semaglutide, a GLP-1 receptor agonist, reduces appetite by acting on GLP-1 receptors in the hypothalamus, increases insulin production, and decreases glucagon secretion, thus delaying gastric emptying. These distinct yet interconnected mechanisms of action of an amylin analog and a GLP-1 receptor agonist appear to synergistically reduce appetite[3-4].
Side effects
The most frequent adverse events were gastrointestinal disorders (e.g., nausea, constipation, and diarrhoea) and administration-site reactions. More participants receiving cagrilintide 0·3-4·5 mg had gastrointestinal adverse events compared with placebo (41%-63% vs 32%), primarily nausea (20%-47% vs 18%)[5].
References
[1] Antonella M D’Ascanio, William H Frishman, & Jamie A Mullally. “Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity.” Cardiology in Review (2024): 83–90.
[2] Juan P Frias. “Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.” Lancet 402 10403 (2023): 720–730.
[2] Juan P Frias. “Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.” Lancet 402 10403 (2023): 720–730.
Supplier
NanjingGuruiteBiotechnologyCo.,Ltd.
Telephone 17326133519
Websitehttps://www.greatpeptide.com
Sichuan Taihui Biotechnology Co., Ltd
Telephone028-87189093 18599944286
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList99317/0.htm
Sichuan Takele Biotechnology Co., Ltd.
Telephone+86-028-64348587 15680781153
Websitehttp://www.takele.cn
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Telephone0571-87213919 17306812703
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1355681/0.htm
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Telephone18014456767 18014456767
Websitehttp://www.jszkhy.com/
Nanjing Yuanpeptide Biotech Co.,Ltd.
Telephone 18168071971
Websitehttp://www.yuan-peptide.com
Shanghai HongTide Biotechnology Co.,Ltd.
Telephone 19961912513
Websitehttps://www.hongtide.com/index.php
Guangzhou Xinyanze Biotechnology Co., LTD
Telephone 18120340186
Websitehttps://www.chemicalbook.com/supplier/25457894/
Xi'an Kono chem co., Ltd.,
Telephone029-029-86107037-8012-8012 18729555803
Websitehttp://www.konochemical.com
Dongguan Jiuzhe Biotechnology Co., Ltd
Telephone 13316572034
Website
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd
Telephone010-53679529 13801208576
Websitehttp://www.chinazhongshuo.com
Shanghai SuperLan Chemcial Technique Centre
Telephone021-2022843681 15618226720
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19886/0.htm
Hangzhou Peptidego Biotech Co.,Ltd.
Telephone0571-87213919
Websitehttp://www.peptidego.com
Shanghai UCHEM Inc.
Telephone+862156762820 +86-13564624040
Websitehttp://www.myuchem.com/
Hebei Lingding Biotechnology Co., Ltd.
Telephone+86-18031140164 +86-19933155420
Websitehttps://www.hbldbiotech.com/
Zhejiang J&C Biological Technology Co.,Limited
Telephone+1-2135480471 +1-2135480471
Websitehttps://www.sarms4muscle.com
DC Chemicals
Telephone021-58447131 13564518121
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm
Shanghai Longyu Biotechnology Co., Ltd.
Telephone +8613917842738
Websitehttps://www.chemicalbook.com/manufacturer/shanghai-longyu-biotechnology-164/
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine