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5-BroMo-4-fluoropyridin-2-amine is a pyridine organic compound used in pharmaceutical synthesis and experiments.

A solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in anhydrous acetonitrile (700 mL) was cooled in an ice-water bath under stirring conditions. Subsequently, N-bromosuccinimide (122.8 g, 0.69 mol) was added in batches. The reaction mixture was stirred continuously for 1 hour at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was washed thoroughly with water (3 x 300 mL) and then dissolved with acetonitrile and again subjected to vacuum evaporation to finally obtain 5-bromo-2-amino-4-fluoropyridine as an off-white solid (124 g, 97% yield).

[1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 108
[2] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 110
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 719 - 724
[4] Patent: WO2018/68283, 2018, A1. Location in patent: Paragraph 00252
[5] Patent: WO2018/68282, 2018, A1. Location in patent: Paragraph 00241