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4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide is a selective BRPF2 bromodomain inhibitor.

OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1BRPF2BRPF3) th at assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complexwhich plays a crucial roles in DNA repairrecombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mMand shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization detailsplease see OF-1 on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targetsvi

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