91893-83-3

Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora. It inhibits IL-1β-induced microsomal prostaglandin E₂ synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM. It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM.

Garcinoic Acid displays anti-angiogenic activity as well as anti-oxidative activity in animals.

Natural product derived from plant source.

Store at -20°C

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] KHALED ALSABIL. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.[J]. Planta medica, 2016, 82 11-12: 1110-1116. DOI: 10.1055/s-0042-108739
[3] KENJI TERASHIMA  Masatake N  Yoshiaki Takaya. Powerful antioxidative agents based on garcinoic acid from Garcinia kola[J]. Bioorganic & Medicinal Chemistry, 2002, 10 5: Pages 1619-1625. DOI: 10.1016/s0968-0896(01)00428-x