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CAS DataBase List
91556-75-1
91556-75-1
Name
RJR-2429 2HCL
CAS
91556-75-1
Molecular Formula
C12H16N2
Molecular Weight
188.27
MOL File
91556-75-1.mol
Synonyms
RJR-2429 2HCL
1-Azabicyclo[2.2.2]octane, 2-(3-pyridinyl)-
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Chemical Properties
Boiling point
295.6±15.0 °C(Predicted)
density
1.11±0.1 g/cm3(Predicted)
storage temp.
Desiccate at RT
solubility
H
2
O: 5 mg/mL
form
solid
pka
9.41±0.40(Predicted)
color
white
Safety Data
WGK Germany
3
Hazard Information
Uses
RJR 2429 is a potent AChR agonist.
Biological Activity
Potent nAChR agonist that displays selectivity for α 4 β 2 (K i = 1 nM) and α 1 β γ δ subtypes (EC 50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC 50 = 2 nM) and inhibits ion flux in thalamic neurons (IC 50 = 154 nM). Also putative α 3 β 4 agonist that potentiates catecholamine release.
Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
Telephone
821-50328103-801 18930552037
Website
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm
TargetMol Chemicals Inc.
Telephone
15002134094
Website
https://www.targetmol.cn/
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