91524-16-2

MOL File

91524-16-2.mol

Synonyms

(-) S Timolol (-)-S-Timolol Timolol hemihydrate (S)-timolol hemihydrate

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Safety Data

Signal word	Warning
Hazard statements	H351-H302-H319
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

Hazard Information

Definition

ChEBI: (S)-timolol hemihydrate is a hydrate, which is the hemihydrate form of the (S)-(-) (more active) enantiomer of timolol. It has a role as an antihypertensive agent, an anti-arrhythmia drug, a beta-adrenergic antagonist and an antiglaucoma drug. It contains a (S)-timolol (anhydrous).

in vivo

Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats^[3].

Animal Model:	Male Wistar rats^[3].
Dosage:	5 mg/kg
Administration:	Timolol (5 mg/kg daily for 12-week)
Result:	Showed cardioprotective effect.

IC 50

β adrenergic receptor

Supplier

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Telephone029-029-029-81148696 18161915376

Websitehttp://www.dideu.cn

LGC Science (Shanghai) Ltd.

Telephone 17717235263

Websitehttps://www.lgcstandards.com/CN/en/Pharmaceutical/cat/279492

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Wuhan Yunyu Biotechnology Co., Ltd.

Telephone15377663271 15377663271

Website

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