Description
8-
iso-
15-
keto Prostaglandin E
2 (8-
iso-
15-
keto PGE
2) is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids.
1 8-
iso-
15-
keto PGE
2 is the theoretical first metabolite of 8-
iso PGE
2 via the 15-
hydroxy PGDH pathway. While a number of potent biological activities have been attributed to 8-
iso PGE
2,
2 there are no published reports at this time regarding its metabolism.
References
1. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc. Natl. Acad. Sci. USA 87(23),9383-9387(1990).
2. Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor Prostaglandins 48,247-256(1994).
