910045-32-8

PQ-69 is a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 exhibits potent antagonist effects on A1AR in vitro, ex vivo and in vivo.

PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208?nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1].

[1] Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10(4):619-29. DOI:10.1007/s11302-014-9424-5