ChemicalBook CAS DataBase List 90989-93-8

90989-93-8

Name	PHOSPHATIDYLETHANOLAMINE
CAS	90989-93-8
EINECS(EC#)	292-752-3
Molecular Formula	C9H18NO8P
MDL Number	MFCD00146358
Molecular Weight	299.215
MOL File	90989-93-8.mol

Chemical Properties

storage temp.	−20°C
solubility	Chloroform: Soluble
form	solution
color	Light yellow to yellow
InChI	InChI=1S/C9H18NO8P/c1-7(11)15-5-9(18-8(2)12)6-17-19(13,14)16-4-3-10/h9H,3-6,10H2,1-2H3,(H,13,14)
InChIKey	CFWRDBDJAOHXSH-UHFFFAOYSA-N
SMILES	P(=O)(O[H])(OC([H])([H])C([H])([H])N([H])[H])OC([H])([H])C([H])(C([H])([H])OC(C([H])([H])[H])=O)OC(C([H])([H])[H])=O
CAS DataBase Reference	90989-93-8

Safety Data

Hazard Codes	T,Xn
Risk Statements	45-46-23/24/25-36/37/38-48/20/22-22-67-40-36/38-20-63 less more
Safety Statements	53-23-36/37/39-45-26-36/37 less more
RIDADR	UN 2810 6.1/PG 2
WGK Germany	3
F	1-8-10

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Phosphatidylethanolamine is abundant in brain tissue, hence its name, cephalin. It coexists with lecithin in various tissues and organs of the body. Its structure and physicochemical properties are similar to those of lecithin, except that in cephalin, cholestylazoline is bound to phosphate.
This product is a complex glycerophospholipid extracted from the brain and spinal cord of livestock. It is a slightly yellowish amorphous powder with a distinctive odor. It has no definite melting point and is optically active. It is soluble in petroleum ether, chloroform, ether, and methanol, slightly soluble in benzene and carbon tetrachloride, and insoluble in water. It is hygroscopic and readily oxidizes to a brown-black color in air. It is an amphoteric compound.

Uses

1,2-Diacyl-sn-glycero-3-phosphoethanolamine is the major structural phopholipids in brain.

Biochem/physiol Actions

The major structural phospholipid in brain, comprising 20-25% of total lipid; primarily localized to gray matter.

in vivo

Phosphatidylethanolamine (375 mg/kg; i.p.) significantly inhibits food intake and locomotor activity in mice^[4].
Phosphatidylethanolamine (2 g added to the basal diet containing 8 g of soybean oil; p.o.; dietary administration; ad libitum; 15-18 days) causes a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE, an increase in high molecular weight apoB, alters the distribution of hepatic phospholipids and the fatty acid composition of serum and hepatic phospholipids in rats^[6].

Animal Model:	Model: Male Wistar rats (weight: 143 g, specific age not mentioned) fed cholesterol-free semipurified diet^[6]
Dosage:	2 g of Phosphatidylethanolamine added to the basal diet containing 8 g of soybean oil
Administration:	Dietary administration, ad libitum, 15-18 days
Result:	Led to a significant decrease in serum cholesteryl ester, phospholipid, apoA-I and apoE, while serum apoB was higher compared to the PC and control groups. Decreased hepatic cholesterol. Altered the relative distribution of phospholipid subclasses in the liver. Altered the fatty acid composition of liver PC and PE. Enhanced the excretion of fecal neutral steroids. Showed higher hepatic HMG-CoA reductase activity.

storage

Store at -20°C

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