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5-Hexynoic Acid-NHS Ester contains a propargyl group and an NHS ester group. This reagent is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

5-Hexynoic NHS Ester is a nonclaevable linker for antibody-drug-conjugation. 5-Hexynoic NHS Ester is used in the preparation of biomimetic G-quartet compounds for detection, imaging and purification of G-quartet nucleic acids.