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Method 5; Synthesis of 1-(5-fluoropyrimidin-2-yl)ethanone; To a round-bottomed flask containing 5-fluoropyrimidine-2-carbonitrile (Method 6, 1.50 g, 12.19 mmol) was added anhydrous tetrahydrofuran (30 mL) under nitrogen protection. The reaction system was cooled to 0 °C and methylmagnesium bromide solution (4.90 mL, 3.0 M ether solution, 14.62 mmol) was added slowly and dropwise. After keeping the reaction at 0 °C for 2 h, the reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure to afford the title compound as an oil (0.778 g, 46% yield).GC-MS showed molecular ion peaks m/z 140 (M); 1H NMR (CDCl3) δ 8.65 (s, 2H), 2.65 (s, 3H).

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