905298-84-2

Name	LIMK1 inhibitor BMS 4
CAS	905298-84-2
Molecular Formula	C23H23N7O2S
MDL Number	MFCD24387531
Molecular Weight	461.54
MOL File	905298-84-2.mol

Synonyms

LIMK1 inhibitor BMS 4 LIMK1 inhibitor BMS 4 - BMS 4 1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea Urea, N-ethyl-N'-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4-pyrimidinyl]-2-thiazolyl]-

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Chemical Properties

Melting point	274-276 °C
density	1.297±0.06 g/cm3(Predicted)
form	Solid
pka	8.63±0.70(Predicted)
color	White to off-white

Hazard Information

Uses

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

IC 50

LIMK1: 7.25 (pIC₅₀); LIMK2: 6.87 (pIC₅₀)

References

[1] Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. DOI:10.1021/acs.jmedchem.2c00751
[2] Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. DOI:10.1158/1535-7163.MCT-08-0826

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

Shandong Dayou Pharmaceutical Research and Development Co., Ltd.

Telephonehanfangpharma@126.com 15165037910

Website

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shaanxi Didu Pharmaceutical Co., Ltd.

Telephone029-81124775 17791530730

Website

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