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Sodium polypectate can be used to sequester metal ions. In fungal cultures, it is used as a carbon source and inducer of polygalacturonases.Polygalacturonic acid has been used in a study to assess an alkaline-active and alkali-stable pectate lyase from Streptomyces sp. S27 with potential in the textile industry. It has also been used in a study that investigated optimization of production and reaction conditions of polygalacturonase from Byssochlamys fulva.

Sodium polypectate sequesters metal ions and, in fungal cultures, it is used as a carbon source and inducer of polygalacturonases.

In land plants, polygalacturonic acids are major components of cell wall polysaccharides (pectins). Bound polygalacturonase-inhibiting peptides (PGIP) protect pectin from degradation by fungal polygalacturonases.