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Epoxide hydrolase is an enzyme responsible for catalyzing the reaction between epoxides and water, converting epoxide groups into diols. Epoxide hydrolase plays a key role in the metabolism of environmental pollutants and lipids, contributing to detoxification, inflammation responses, and the regulation of cardiovascular system health. Additionally, epoxide hydrolase can be used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, to produce chiral drug molecules[1][2].

Epoxide hydrolase is an enantioselective catalyst for the hydrolytic kinetic resolution of epoxides.

[1] Jacobsen EN. Asymmetric catalysis of epoxide ring-opening reactions. Acc Chem Res. 2000 Jun;33(6):421-31. DOI:10.1021/ar960061v