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• Synthesis

  Using readily available and inexpensive adipic acid (1) as the starting material, 3-OXA-8-AZABICYCLO[3.2.1]OCTANE, HYDROCHLORIDE (1:1) was synthesized through eight steps: acyl chloride, bromination, benzylamine cyclization, hydrolysis, reduction, dehydration cyclization, hydrodebenzylation, and salt formation. The synthetic route is shown below.

  

  Figure 1 Synthetic route of 3-OXA-8-AZABICYCLO[3.2.1]OCTANE, HYDROCHLORIDE (1:1)

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