904304-57-0

1,2-Dierucoyl->sn-glycero-3-PE is a phospholipid containing erucic acid (13(Z)-docosenoic acid; Item No. 90175) at the sn-1 and sn-2 positions. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 1,2-Dierucoyl-sn-glycero-3-PE has also been used in the synthesis of various PEG-conjugates for incorporation into liposomes.2,3,4 LNPs containing 1,2-dierucoyl-sn-glycero-3-PE and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.1WARNING This product is not for human or veterinary use.

[1] AMITA VAIDYA, FRANK DEROSA   Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation[J]. Analytical Chemistry, 2024, 96 14: 5570-5579. DOI: 10.1021/acs.analchem.4c00031
[2] KENNETH J LONGMUIR. Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence.[J]. Pharmaceutical Research, 2006, 23 4: 759-769. DOI: 10.1007/s11095-006-9609-x
[3] SHERRY M HAYNES. Liposomal polyethyleneglycol and polyethyleneglycol-peptide combinations for active targeting to liver in vivo.[J]. Drug Delivery, 2008, 15 4: 207-217. DOI: 10.1080/10717540802006211
[4] MONICA S TSAI. Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity.[J]. Journal of Drug Targeting, 2011, 19 7: 506-515. DOI: 10.3109/1061186x.2010.511227