ChemicalBook CAS DataBase List 4004-05-1

4004-05-1

Name	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
CAS	4004-05-1
EINECS(EC#)	200-663-8
Molecular Formula	C41H78NO8P
MDL Number	MFCD00057986
Molecular Weight	744.03
MOL File	4004-05-1.mol

Chemical Properties

Melting point	200°C(lit.)
Boiling point	759.2±70.0 °C(Predicted)
density	1.008±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO: 31.25 mg/mL (42.00 mM)
form	lyophilized powder
pka	1.17±0.50(Predicted)
color	White to Light yellow
BRN	1718431
InChIKey	MWRBNPKJOOWZPW-XFBMKQTANA-N
SMILES	[C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC \|&1:0,r\|

Safety Data

Hazard Codes	Xn
Risk Statements	22-38-40-48/20/22-67-36/38-20-63 less more
Safety Statements	36/37-26 less more
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
F	8-10-23
HS Code	29232000

Hazard Information

Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE,4004-05-1) is a neutral phospholipid and displays sensitivity towards pH change and has been used in the preparation of liposome and giant unilamellar vesicles (GUVs).
Phosphatidylethanolamine (PE) is formed primarily in the reaction of CDP-ethanolamine and diacylglycerol. PE is one of the major components of cell membranes in bacteria and in nervous system.

Chemical Properties

Yellowish wax

Uses

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE,4004-05-1) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.

Application

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE,4004-05-1) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Definition

ChEBI: Dioleoyl phosphatidylethanolamine is a phosphatidylethanolamine in which the phosphatidyl acyl groups are both oleoyl.

General Description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE,4004-05-1)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.

Biological Activity

DOPE(4004-05-1) in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

Biochem/physiol Actions

DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

storage

Store at -20°C

Spectrum Detail

Supplier

Suzhou Highfine Biotech Co., Ltd

Telephone0512-69209928 18306219933

Websitehttps://www.highfine.com

Shochem(Shanghai)Co.,Ltd

Telephone+86-021-51783479 +86-13816874662

Websitehttp://www.shochem.com

Shandong Huishengtang Biological Medicine Co., Ltd.

Telephone0533-8082186 18853399702

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1989503/0.htm

Guangzhou Weihua Biotechnology Co., Ltd

Telephone020-020-37239396 18922492046

Websitehttp://www.weihuasw.com

Shochem (Shanghai) Co.,Ltd

Telephone13611745246 13816874662

Websitehttps://www.shochem.com/

Chongqing Yusi medical technology cable Co., Ltd.

Telephone19923757617 18896157519

Websitehttp://www.yusiyy.com/

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-400-6206333 18521732826

Websitehttp://www.aladdin-e.com/

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Bide Pharmatech Ltd.

Telephone400-164-7117 13681763483

Websitehttp://www.bidepharm.com

Yichang Zhongyitai Trading Co., Ltd.

Telephone0717-6449896 13886658719

Websitehttp://www.zhongyitai.com/

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Telephone 400-8592883 15367835770

Websitehttp://www.huatengsci.com

Shanghai Macklin Biochemical Co.,Ltd.

Telephone15221275939 15221275939

Websitehttp://www.macklin.cn

Shanghai AECOM Biotechnology Co. , Ltd.

Telephone021-021-20956531 18116226605

Websitehttps://www.aykbio.com

Hubei Jusheng Technology Co.,Ltd

Telephone027-59599241 18871490274

Websitehttp://www.jushengtech.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone021-61312847; 18021002903

Websitehttp://www.shyuanye.com

1of4

Send Inquriy