ChemicalBook CAS DataBase List 9036-88-8

9036-88-8

Name	MANNAN
CAS	9036-88-8
MDL Number	MFCD00131574

Chemical Properties

refractive index	78.5 ° (C=1.4, H2O)
storage temp.	2-8°C
form	powder
color	Off-white to light yellow
biological source	Saccharomyces cerevisiae
Optical Rotation	[α]25/D 73 to 82 °, c =1% (w/v) in water
Water Solubility	water: ~50g/L
Merck	5744
Cosmetics Ingredients Functions	FILM FORMING
CAS DataBase Reference	9036-88-8

Safety Data

Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	22-26-36-24/25 less more
WGK Germany	3
RTECS	OP1949500

Hazard Information

Uses

Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. It has also been used in a study to investigate new lectins from bulbs of Croccus sativum.

General Description

Mannan from Saccharomyces cerevisiae is a simple polysaccharide.

Biological Activity

Mannan exhibits several biological propertiesincluding antiproliferativeantioxidantand immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherenceregulation of bacterial growthand enhancement of the immune response.

in vivo

Mannan (50-500 ppm; p.o., dietary; daily; 4 weeks) reduces Aflatoxin B₁ (HY-N6615)-induced toxicity in mice, as evidenced by increased body weight, decreased rate of normochromatic erythrocytes with micronuclei, and decreased rate of sister chromatid exchanges^[2].
Mannan (50-100 mg/kg; i.p.; 2-5 times) reduces serum levels of low-density lipoprotein (LDL), cholesterol, and triglycerides in mice with acute dyslipidemia induced by poloxamer 407 (HY-D1005)^[4].

Animal Model:	Male CBA/Lac mice (2.5-3-month-old, weighing 22-25 g), acute lipemia induced by poloxamer 407 model^[4]
Dosage:	50 mg/kg, 100 mg/kg
Administration:	Intraperitoneal injection, 5 times at 50 mg/kg every other day or 2 times at 100 mg/kg with 1-day interval
Result:	Reduced the levels of triglyceride, atherogenic LDL, and total cholesterol in the serum at 50 mg/kg and 100 mg/kg. Decreased the triglyceride concentration in the liver. Increased the lability of lysosomal membranes in the liver and elevated the serum activity of chitotriosidase, a marker of macrophage activation.

Spectrum Detail

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