903580-39-2

PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility[1].

5-HT₆ Receptor: 4-8 nM (Ki); 5-HT₆ Receptor: 19 nM (IC₅₀); 5-HT_1B Receptor: 260 nM (Ki); 5-HT_1A Receptor: 420 nM (Ki); 5-HT_1D Receptor: 2.8 μM (Ki); 5-HT_2A Receptor: 2.5 μM (IC₅₀); 5-HT_2B Receptor: 2.5 μM (IC₅₀); 5-HT_2C Receptor: 3.7 μM (IC₅₀); Dopamine D3 Receptor: 71 nM (Ki); Opioid μ Receptor: 0.45 μM (Ki); Histamine H2 Receptor: 0.64 μM (Ki)

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[1] Eric G Mohler, et al. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. DOI:10.1007/s00213-011-2518-7