Synthesis
(1) Carbazole (8.36 g, 0.05 mol), 1,2-dibromobenzene (17.69 g, 0.075 mol) and potassium carbonate (17.97 g, 0.13 mol) were added to a reactor under the protection of nitrogen and stirred thoroughly. Subsequently, cuprous iodide (1.91 g) and L-lysine (1.46 g) were added to the system, heated to 163 °C and maintained for 38 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched by the addition of large amounts of water and the solid product was precipitated by stirring. The solid was collected by filtration and dried to give 13.37 g of 9-(2'-bromophenyl)carbazole in 83% yield.
References
[1] Patent: CN106674083, 2017, A. Location in patent: Paragraph 0014; 0015
[2] Chemical Communications, 2011, vol. 47, # 17, p. 5079 - 5081
[3] Chemistry - A European Journal, 2016, vol. 22, # 29, p. 10136 - 10149
[4] Dyes and Pigments, 2017, vol. 136, p. 255 - 261
[5] Patent: KR2015/2243, 2015, A. Location in patent: Paragraph 0040-0043
