ChemicalBook CAS DataBase List 9025-82-5

9025-82-5

Name	PHOSPHODIESTERASE I
CAS	9025-82-5
EINECS(EC#)	232-806-5
Molecular Formula	NULL
MDL Number	MFCD00131883

Chemical Properties

storage temp.	−20°C
form	crude dried venom
color	White to off-white
biological source	Crotalus adamanteus venom
Specific Activity	≥20.0unit/mg solid

Safety Data

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H334
Precautionary statements	P261-P284-P304+P340-P342+P311a-P501a
Hazard Codes	T+
Risk Statements	26/27/28 less more
Safety Statements	36/37/39-45 less more
RIDADR	2811
WGK Germany	3
RTECS	SZ5999500
HazardClass	6.1(a)
PackingGroup	II
Storage Class	13 - Non Combustible Solids
Hazard Classifications	Resp. Sens. 1

Raw materials And Preparation Products

Hazard Information

Description

The food enzyme phosphodiesterase I (oligonucleotide 5′‐nucleotidohydrolase; EC 3.1.4.1) is produced with the non‐genetically modified Leptographium procerum strain FDA by DSM Food Specialties B.V. The food enzyme is free from viable cells of the production organism. It is intended to be used to process yeast and yeast products. Phosphodiesterase I exhibits phosphohydrolase activity against NAD, nucleoside diphosphate sugars, and nucleoside tniphosphates. The enzyme was first isolated from rattlesnake venom and has been the subject of several reviews. Razzell partially purified a mammalian PDE I from a porcine kidney, and subsequent cell fractionation studies by other workers demonstrated the enzyme in the plasma membrane of rat liver cells[1-2].

References

[1] D J Morley. “Distribution of phosphodiesterase I in normal human tissues.” Journal of Histochemistry & Cytochemistry 35 1 (1987): 75–82.
[2] on Food Contact Materials, EFSA Panel Enzymes and Processing Aids (CEP). “Safety evaluation of the food enzyme phosphodiesterase I from the non-genetically modified Leptographium procerum strain FDA.” EFSA Journal 22 4 (2024).

Uses

Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP.

Biochem/physiol Actions

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.

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