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Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS)[1].

ChEBI: Montirelin is an oligopeptide.

Persistent infection with hepatitis C virus (HCV) is a common cause of chronic liver diseaseincluding chronic hepatitiscirrhosisand hepatocellular carcinoma. HCV is an envelopedsingle-stranded RNA virus with a 9.6-kb positive-polarity genomewhich encodes a polyprotein precursor of about 3,000 amino acids. The HCV polyprotein is proteolytically processed by cellular and HCV proteases into at least 10 distinct products. NS3 serine protease and helicase as well as NS5B RNA-dependent RNA polymerase are believed to be components of a replication complex responsible for viral RNA replication and have been shown to be essential for the HCV replication in chimpanzees. These HCV enzymes have been the major targets for the development of HCV-specific therapeutics during the past decade.The HCV NS3/4A protease is responsible for cleavage at four sites within the HCV polyprotein to generate the N termini of the NS4ANS4BNS5Aand NS5B proteins. It has been shown th at the central reg

[1] Urayama A, et al., Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues. Life Sci. 2001 Dec 28;70(6):647-57. DOI:10.1016/s0024-3205(01)01445-x