Human Factor XI can be activated by factor XIIa to factor XIa. Human Factor XI can be used for the study of antithrombotic[1].
References
[1] L?wenberg EC, et al. Coagulation factor XI as a novel target for antithrombotic treatment. J Thromb Haemost. 2010 Nov;8(11):2349-57. DOI:10.1111/j.1538-7836.2010.04031.x