ChemicalBook CAS DataBase List 9008-97-3

9008-97-3

Name	PHYTOHEMAGGLUTININ PHA-M
CAS	9008-97-3
EINECS(EC#)	232-718-7
MDL Number	MFCD00165279

Chemical Properties

storage temp.	2-8°C
solubility	PBS: 2 mg/mL
form	salt-free, lyophilized powder
color	White to light yellow
biological source	Phaseolus vulgaris
Cosmetics Ingredients Functions	SKIN CONDITIONING - MISCELLANEOUS

Safety Data

Safety Statements	22-24/25 less more
WGK Germany	WGK 3
RTECS	TJ3470000
F	10-21
Storage Class	11 - Combustible Solids

Hazard Information

Uses

Phytohemagglutinin-M (PHA-M) has been used in the activation of Jurkat and primary cells. It has also been used to treat polymorphonuclear blood cells(PMBCs)

General Description

Lectins are distinct proteins or glycoproteins that have at least one non-catalytic domain which fixes reversibly to a definite mono- or oligosaccharide. Some of their potentially utilizable biological assets include: antitumor, immunomodulatory and anti-insect, antifungal, antibacterial, anti-HIV, and mitogenic properties.

Biochem/physiol Actions

Phytohemagglutinin (PHA) has mitogenic and potent cell agglutinating activities. It binds to T-cell membranes and stimulates cell division and metabolic activity. PHA has the ability to stimulate close contacts between cell membranes.

Enzyme inhibitor

This class of toxic plant lectins (MW depends on species; CAS 9008-97-3) is a carbohydrate-binding protein, consisting mainly of the leukoagglutinins PHA-L and PHA-E, indicating their ability to agglutinate leukocytes and erythrocytes. Phytohemagglutinins occur at the highest concentrations in uncooked red and white kidney beans, green beans, broad beans, and fava beans. Phaseolus vulgaris phytohemagglutinin consists of seven different glycosylated polypeptides. Phytohemagglutinins induce mitosis, alter membrane transport, and increase membrane permeability to proteins. In humans, poisoning can be induced from as few as five raw beans, with symptoms occurring within three hours, beginning with nausea, then vomiting, followed by diarrhea. Medical intervention is rarely required.

in vivo

Phytohemagglutinin (100 μg; i.p.; daily for 2 days) inhibits A20 tumor growth^[1].

Animal Model:	CB17-SCID Mice (bearing A20 cells)^[1]
Dosage:	100 μg
Administration:	I.p.; daily for 2 days
Result:	Inhibited A20 tumor growth.

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