89159-60-4

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC₅₀ = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC₅₀ = 10 μM) in isolated human platelets.

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

140 nm

Store at -20°C

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.