890402-81-0

Name	Dutogliptin tartrate
CAS	890402-81-0
Molecular Formula	C14H26BN3O9
MDL Number	MFCD28396944
Molecular Weight	391.18
MOL File	890402-81-0.mol

Synonyms

PHX-1149 Dutogliptin tartrate

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Hazard Information

Uses

Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

in vivo

Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a T_max of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s^[2].

References

[1] Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. DOI:10.1002/cpdd.87
[2] Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55. DOI:10.1111/j.1463-1326.2010.01195.x

Supplier

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Anqing Chico Pharmaceutical Co., Ltd.

Telephone15380796838

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30721/0_EN.htm

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