Description
Goniothalesdiol, isolated from the bark of the Malaysian tree
G. borneensis, is a tetrahydrofuran compound known to have significant cytotoxic effects against P388 murine leukemia cells and pesticidal activities.
1,2 (+)-
2,5-
epi-
Goniothalesdiol is a goniothalesdiol analog.
3 Little is known of its biological activity.
Uses
(+)-2,5-epi-Goniothalesdiol is an analogue of Goniothalesdiol, which exhibits significant cytotoxicity against P388 mouse leukemia cells and has insecticidal activity. (+)-2,5-epi-Goniothalesdiol can be synthesized starting from D-mannitol (HY-N0378)[1].
References
1. Prasad, K.R., and Gholap, S.L. An expeditious enantiospecific total synthesis of (+)-7-epi-goniofufurone Synlett 14,2260-2262(2005).
2. Blázquez, M.A., Bermejo, A., Zafra-Polo, M.C., et al. Styryl-lactones from Goniothalamus species-a review Phytochem. Anal. 10(4),161-170(1999).
3. Prasad, K.R., and Gholap, S.L. Stereoselective synthesis of (+)-goniothalesdiol J. Org. Chem. 71(9),3643-3645(2006).
