886563-25-3

Name	ZK-261991
CAS	886563-25-3
Molecular Formula	C24H25N7O2
MDL Number	MFCD25976709
Molecular Weight	443.5
MOL File	886563-25-3.mol

Synonyms

ZK 991 ZK-991 ZK-261991 ZK261991(ZK991) ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991 Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-

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Chemical Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO

Hazard Information

Uses

ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2.

in vivo

ZK991 results in a significantly reduced recruitment of CD11b⁺ and LYVE-1⁺ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation^[1].

IC 50

VEGFR2: 5 nM (IC₅₀)

storage

Store at -20°C

References

[1] Deniz Hos, et al. Inflammatory Corneal (Lymph)angiogenesis Is Blocked by VEGFR-Tyrosine Kinase Inhibitor ZK 261991, Resulting in Improved Graft Survival after Corneal Transplantation. Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1836-184

Supplier

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

cjbscvictory

Telephone13348960310 13348960310

Websitehttps://www.weikeqi-biotech.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

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