105114-63-4

ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].

[1] C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268(13):9262-6. PMID:8387487
[2] Claudia Lanari, et al.? Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19(3):R35-50. DOI:10.1530/ERC-11-0378