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tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate can be used to synthesize ketohexokinase (KHK) inhibitors that have potential medical uses for treating diabetes and obesity.??tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate is also a useful reagent for the synthesis of dihydroisoindolecarboxamide derivatives as??Nicotinamide Phosphoribosyltransferase (NAMPT) and??Rho-associated protein kinase (ROCK)??inhibitors.

2,6-diazaspiro[3.4]octane is the main structure of Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate. The fully saturated, high-Fsp3 2,6-diazaspiro[3.4]octane core is an emerging privileged structure, taking into account its recent frequent appearance in compounds possessing diverse biological activities. Notable recently reported examples include a hepatitis B capsid protein inhibitor, a menin-MLL1 interaction inhibitor for the treatment of cancer, a MAP and PI3K signaling modulator, a selective dopamine D3 receptor antagonist, and VDAC1 inhibitors for the treatment of diabetes^[1].

[1] Lukin, A.; Komarova, K.; Vinogradova, L.; Dogonadze, M.; Vinogradova, T.; Yablonsky, P.; Kazantsev, A.; Krasavin, M. Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead. Molecules 2023, 28, 2529. DOI:10.3390/molecules28062529