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Hypothalamic RFamide-related neuropeptide. Acts as a natural ligand of the orphan receptor GPR103. Exhibits orexigenic acitivity in mice upon central administration.

Frog 26RFa is a neuropeptide that can be isolated from frog brain. Frog 26RFa has pro-oxygen activity[1].

[1] Chartrel, et al. "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity." Proceedings of the National Academy of Sciences 100.25 (2003): 15247-15252. DOI:10.1073/pnas.2434676100