878207-28-4

Methyl 2-bromo-4,5-difluorobenzoate is used as a pharmaceutical intermediate.

Methyl 2-bromo-4,5-difluorobenzoate was prepared as follows: to a mixture of 2-bromo-4,5-difluorobenzoic acid (1 g, 4.22 mmol) in dichloromethane (10 mL) and MeOH (1 mL) was added trimethylmethylsilyl) diazomethane (2.110 mL, 4.22 mmol) and the reaction s