ChemicalBook CAS DataBase List 872044-70-7

872044-70-7

Name	AN-0128
CAS	872044-70-7
Molecular Formula	C20H16BCl2NO3
MDL Number	MFCD18251581
Molecular Weight	400.063
MOL File	872044-70-7.mol

Chemical Properties

storage temp.	4°C, protect from light
solubility	DMSO : 125 mg/mL (312.45 mM; Need ultrasonic)
form	Solid
color	White to off-white

Hazard Information

Uses

AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases[1][2].

in vivo

AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss^[2].

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)^[2]
Dosage:	1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle
Administration:	Daily topical daub for 7 days
Result:	Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)^[2]
Dosage:	5% with Total toothpaste
Administration:	Applied daily via a cotton-tip applicator. for 7 days
Result:	Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss.

storage

4°C, protect from light

References

[1] Baker SJ, et al. Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5963-7. DOI:10.1016/j.bmcl.2006.08.130
[2] Luan Q, et al. Inhibition of experimental periodontitis by a topical boron-based antimicrobial. J Dent Res. 2008 Feb;87(2):148-52. DOI:10.1177/154405910808700208

Spectrum Detail

Supplier

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